Readjudication

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1. WO2025160218 – Improved Linkers and Methods for the Synthesis of Anti-Transferrin Receptor Antibody Conjugates

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ARROWHEAD PHARMACEUTICALS [$ARWR] filed a patent application for an anti-transferrin receptor antibody linking for it’s RANi therapies.

This correlates with drug delivery to the brain as TfR1 antibodies are taken up through the blood brain barrier.

This technology does correlate with their phase 1 SCA therapy in development ARO-ATXN2

However, RNAi delivery to the brain could result in development of targeted therapies for MCI and Dementia which is already being pushed in the mAb development space aggressively.

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Anthony Taylor

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